The Most Comprehensive Source of Stereology Information on the Web

What is Stereology.info?

Stereology.info includes a wide range of knowledge about stereology. This site introduces both basic and advanced concepts in the field. The emphasis is on its use in biological research, though anyone interested in learning concepts of stereology will find something of interest. The application of stereological methods to biological studies permits researchers to effectively and efficiently gather data. This site is dedicated to helping researchers understand the principles of design-based stereology and its advantages over less sophisticated approaches in quantitative histology.

Design-based stereology is a set of methods to ensure rigorous quantitative analysis of the size, shape, and number of objects. When properly used, stereology plays an important role in validating and rejecting experimental hypotheses in biological research. It produces results that are unbiased, efficient, and more reliable than other ad hoc quantitative analyses. Unbiased stereology provides an important contribution to the advancement in biological research by improving the consistency and dependability of quantitative analytical results produced in the laboratory and reported in scientific publications.

The Counting Frame is a fundamental tool in stereological research.

Stereo Investigator continues to be the leading stereology system

In 2014 researchers used Stereo Investigator in 698 peer-reviewed papers – citing it nearly three times as all other stereology systems combined. These researchers tell us the reasons it continues to be the most widely used system for unbiased stereology are:

  1. it works with many different microscopes and imaging technologies
  2. it provides unbiased data about neuron populations and regions of interest
  3. of the with strong technical and research support provided by MBF Bioscience
2014
source: google scholar

Dr. Mark West, co-developer of the Optical Fractionator stereology probe and Professor of Medical Neurobiology at Aarhus University in Denmark, says “Stereo Investigator is the most reliable tool for collecting unbiased stereology data. It’s backed by excellent technical and research support teams at MBF – you can call to ask about stereology probes, tissue preparation, microscope hardware, basically anything regarding your stereology study.”

Continue reading “2014: An outstanding year for Stereo Investigator” »

 

Recent Noteworthy Stereology Publications

Published papers using unbiased stereology; last updated on 05/20/2014.

starindicates that the researchers did a good job reporting stereological parameters.

starReduced Number of Pigmented Neurons in the Substantia Nigra of Dystonia Patients? Findings from Extensive Neuropathologic, Immunohistochemistry, and Quantitative Analyses

Early-life stress increases the survival of midbrain neurons during postnatal development and enhances reward-related and anxiolytic-like behaviors in a sex-dependent fashion

starProgressive Cognitive Deficit, Motor Impairment and Striatal Pathology in a Transgenic Huntington Disease Monkey Model from Infancy to Adulthood

Treatment with Trehalose Prevents Behavioral and Neurochemical Deficits Produced in an AAV α-Synuclein Rat Model of Parkinson’s Disease

Chick embryos have the same pattern of hypoxic lower-brain activation as fetal mammals

Dual target strategy: combining distinct non-dopaminergic treatments reduces neuronal cell loss and synergistically modulates L-DOPA-induced rotational behavior in a rodent model of Parkinson’s disease

Intrathecal enzyme replacement therapy improves motor function and survival in a preclinical mouse model of infantile neuronal ceroid lipofuscinosis

Aberrant hippocampal neurogenesis after limbic kindling: Relationship to BDNF and hippocampal-dependent memory

The Effect of Estrogen Usage on Eccentric Exercise-Induced Damage in Rat Testes

Repeated, high-dose dextromethorphan treatment decreases neurogenesis and results in depression-like behavior in rats

Effect of perinatally supplemented flavonoids on brain structure, circulation, cognition, and metabolism in C57BL/6J mice

Granulosa Cell-Specific Brca1 Loss Alone or Combined with Trp53 Haploinsufficiency and Transgenic FSH Expression Fails to Induce Ovarian Tumors

starDegeneration in Arousal Neurons in Chronic Sleep Disruption Modeling Sleep Apnea

Monocyte Traffic, Dorsal Root Ganglion Histopathology, and Loss of Intraepidermal Nerve Fiber Density in SIV Peripheral Neuropathy

An adipogenic gel for surgical reconstruction of the subcutaneous fat layer in a rat model

star A rat model of nerve agent exposure applicable to the pediatric population: The anticonvulsant efficacies of atropine and GluK1 antagonists

MDMA-induced loss of parvalbumin interneurons within the dentate gyrus is mediated by 5HT2A and NMDA receptors

Characterization of long-term motor deficits in the 6-OHDA model of Parkinson’s disease in the common marmoset

Acupuncture attenuates cognitive deficits and increases pyramidal neuron number in hippocampal CA1 area of vascular dementia rats

ApoE Regulates Injury-Induced Activation of Hippocampal Neural Stem and Progenitor Cells

Activin A Protects Midbrain Neurons in the 6-Hydroxydopamine Mouse Model of Parkinson’s Disease

Selective blockade of mGlu5 metabotropic glutamate receptors is protective against hepatic mitochondrial dysfunction in 6-OHDA lesioned Parkinsonian rats

Developmental stage-dependent impact of midazolam on calbindin, calretinin and parvalbumin expression in the immature rat medial prefrontal cortex during the brain growth spurt

Npas4 deficiency increases vulnerability to juvenile stress in mice

Periostin Promotes Neural Stem Cell Proliferation and Differentiation following Hypoxic-Ischemic Injury

Positively charged oligo[poly(ethylene glycol) fumarate] scaffold implantation results in a permissive lesion environment after spinal cord injury in rat

Small Peptide Inhibitor of JNK3 Protects Dopaminergic Neurons from MPTP Induced Injury via Inhibiting the ASK1-JNK3 Signaling Pathway

Cerebrovascular and blood–brain barrier impairments in Huntington’s disease: Potential implications for its pathophysiology

Continuous High-Frequency Stimulation of the Subthalamic Nucleus Improves Cell Survival and Functional Recovery Following Dopaminergic Cell Transplantation in Rodents

Striatal tyrosine hydroxylase-positive neurons are associated with l-DOPA-induced dyskinesia in hemiparkinsonian mice

Erythropoietin-mediated neuroprotection in a pediatric mouse model of chronic hypoxia

Postnatal Loss of Hap1 Reduces Hippocampal Neurogenesis and Causes Adult Depressive-Like Behavior in Mice

Convergence of lemniscal and local excitatory inputs on large gabaergic tectothalamic neurons

starThe impact of slaughter age on performance, carcass traits, properties of cutup pieces of carcasses, and muscle development in broiler chickens

Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock in mice

Guanidinylated block copolymers for gene transfer: A comparison with amine-based materials for in vitro and in vivo gene transfer efficiency

Serum- glucocorticoid-inducible kinase 1 confers protection in cell-based and in in vivo neurotoxin models via the c-Jun N-terminal kinase signaling pathway

Hypoxic preconditioning can reduce injury-induced inflammatory processes in the neonatal rat brain

A Nurr1 Agonist Causes Neuroprotection in a Parkinson’s Disease Lesion Model Primed with the Toll-Like Receptor 3 dsRNA Inflammatory Stimulant Poly(I:C)

starA Novel Triple Repeat Mutant Tau Transgenic Model That Mimics Aspects of Pick’s Disease and Fronto-Temporal Tauopathies

Continue reading “Recent Noteworthy Stereology publications”

 

 

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developers of Stereo Investigator, the world’s most cited stereology system