The Most Comprehensive Source of Stereology Information on the Web

 

What is Stereology.info?

Stereology.info, the Stereology Information Center, includes a wide range of knowledge about stereology. This site introduces both basic and advanced concepts in the field. The emphasis is on its use in biological research, though anyone interested in learning concepts of stereology will find something of interest. The application of stereological methods to biological studies permits researchers to effectively and efficiently gather data. This site is dedicated to helping researchers understand the principles of design-based stereology and its advantages over less sophisticated approaches in quantitative histology.

Design-based stereology is a set of methods to ensure rigorous quantitative analysis of the size, shape, and number of objects. When properly used, stereology plays an important role in validating and rejecting experimental hypotheses in biological research. It produces results that are unbiased, efficient, and more reliable than other ad hoc quantitative analyses. Unbiased stereology provides an important contribution to the advancement in biological research by improving the consistency and dependability of quantitative analytical results produced in the laboratory and reported in scientific publications.

The Counting Frame is a fundamental tool in stereological research.

Recent Noteworthy Stereology Publications

Published papers using unbiased stereology; last updated on 12/16/2014, star indicates that the researchers did an exemplary job reporting stereological parameters

810 nm near-infrared light offers neuroprotection and improves locomotor activity in MPTP-treated mice

Elevated spinal monoamine neurotransmitters after antenatal hypoxia-ischemia in rabbit cerebral palsy model

c-Fos induction in mesotelencephalic dopamine pathway projection targets and dorsal striatum following oral intake of sugars and fats in rats

The problem of axonal injury in the brains of veterans with histories of blast exposure

Label-free, three-dimensional multiphoton microscopy of the connective tissue in the anterior vaginal wall

Differential Effects of Delayed Aging on Phenotype and Striatal Pathology in a Murine Model of Huntington Disease

Repetitive mild traumatic brain injury with impact acceleration in the mouse: Multifocal axonopathy, neuroinflammation, and neurodegeneration in the visual system

Posttraining Ablation of Adult-Generated Olfactory Granule Cells Degrades Odor–Reward Memories

star Inhibiting drug efflux transporters improves efficacy of ALS therapeutics

Long-lasting suppression of acoustic startle response following mild traumatic brain injury

Early-Stage Treatment with Withaferin A Reduces Levels of Misfolded Superoxide Dismutase 1 and Extends Lifespan in a Mouse Model of Amyotrophic Lateral Sclerosis

Sex-specific effects of relaxin-3 on food intake and brain expression of corticotropin-releasing factor in rats

Regional Difference in Sex Steroid Action on Formation of Morphological Sex Differences in the Anteroventral Periventricular Nucleus and Principal Nucleus of the Bed Nucleus of the Stria Terminalis

Reduced cerebellar neurodegeneration after combined therapy with cyclodextrin/allopregnanolone and miglustat in NPC1: A mouse model of Niemann-Pick type C1 disease

Characterization of recovery, repair, and inflammatory processes following contusion spinal cord injury in old female rats: is age a limitation?

A Comparison of Three Electrophysiological Methods for the Assessment of Disease Status in a Mild Spinal Muscular Atrophy Mouse Model

Loss of Mitochondrial Fission Depletes Axonal Mitochondria in Midbrain Dopamine Neurons

Olfactory Epithelium in the Olfactory Recess: A Case Study in New World Leaf-Nosed Bats

Physical exercise-induced hippocampal Neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin

Knockdown of ventral tegmental area mu-opioid receptors in rats prevents effects of social defeat stress: Implications for amphetamine cross-sensitization, social avoidance, weight regulation and expression of brain-derived neurotrophic factor

Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas

star Stereological Study of Amygdala Glial Populations in Adolescents and Adults with Autism Spectrum Disorder 

Baclofen facilitates sleep, neuroplasticity, and recovery after stroke in rats

Associations among exposure to methylmercury, reduced Reelin expression, and gender in the cerebellum of developing mice

The Netrin/RGM Receptor, Neogenin, Controls Adult Neurogenesis by Promoting Neuroblast Migration and Cell Cycle Exit

Stereological investigation of the posterior hippocampus in affective disorders

Influenza A(H1N1) vaccination during early pregnancy transiently promotes hippocampal neurogenesis and working memory. Involvement of Th1/Th2 balance

Developmental exposure to SSRIs, in addition to maternal stress, has long-term sex-dependent effects on hippocampal plasticity

Recombinant adenoassociated virus 2/5-mediated gene transfer is reduced in the aged rat midbrain

The Epithelial-Mesenchymal Transition Factor SNAIL Paradoxically Enhances Reprogramming

Endogenous neural stem/progenitor cells stabilize the cortical microenvironment following traumatic brain injury

AAV.shRNA-mediated downregulation of ROCK2 attenuates degeneration of dopaminergic neurons in toxin-induced models of Parkinson’s disease in vitro and in vivo

Chronic wheel running-induced reduction of extinction and reinstatement of methamphetamine seeking in methamphetamine dependent rats is associated with reduced number of periaqueductal gray dopamine neurons

Differential susceptibility to chronic social defeat stress relates to the number of Dnmt3a-immunoreactive neurons in the hippocampal dentate gyrus

Astrocytes show reduced support of motor neurons with aging that is accelerated in a rodent model of ALS

Neuroprotective effects of aldehyde dehydrogenase 2 activation in rotenone-induced cellular and animal models of parkinsonism

Methamphetamine affects cell proliferation in the medial prefrontal cortex: A new niche for toxicity

Deficit in sustained attention following selective cholinergic lesion of the pedunculopontine tegmental nucleus in rat, as measured with both post-mortem immunocytochemistry and in vivo PET imaging with [18F]fluoroethoxybenzovesamicol

Alpha-synuclein as a Pathological Link between Chronic Traumatic Brain Injury and Parkinson’s disease

Cux2 activity defines a subpopulation of perinatal neurogenic progenitors in the hippocampus

Nonclinical evaluation of CNS-administered TPP1 enzyme replacement in canine CLN2 neuronal ceroid lipofuscinosis

Chronic decrease in wakefulness and disruption of sleep-wake behavior after experimental traumatic brain injury

Stereological study of the neuronal number and volume of 38 brain subdivisions of subjects diagnosed with autism reveals significant alterations restricted to the striatum, amygdalaand cerebellum

Blockade of excitatory synaptogenesis with proximal dendrites of dentate granule cells following rapamycin treatment in a mouse model of temporal lobe epilepsy

Survival of Neural Stem Cell Grafts in the Lesioned Spinal Cord Is Enhanced by a Combination of Treadmill Locomotor Training via Insulin-Like Growth Factor-1 Signaling

Deficiency of Trim27 protects dopaminergic neurons from apoptosis in the neurotoxin model of Parkinson׳s disease

Adenosine kinase, glutamine synthetase and EAAT2 as gene therapy targets for temporal lobe epilepsy

Highly potent soluble amyloid-β seeds in human Alzheimer brain but not cerebrospinal fluid

Neonatal onset of leptin signaling in dopamine neurons of the ventral tegmental area in the rat

Wild-type bone marrow transplant partially reverses neuroinflammation in progranulin-deficient mice

Intravenous immunoglobulin G improves neurobehavioral and histological outcomes after traumatic brain injury in mice

Conditional Deletion of α-CaMKII Impairs Integration of Adult-Generated Granule Cells into Dentate Gyrus Circuits and Hippocampus-Dependent Learning

Early Expression of Hypocretin/Orexin in the Chick Embryo Brain

star Cannabinoid CB2 receptor (CB2R) stimulation delays rubrospinal mitochondrial-dependent degeneration and improves functional recovery after spinal cord hemisection by ERK1/2 inactivation

Regulation of fibroblast lipid-storage and myofibroblast phenotypes during alveolar septation in mice

Hippocampal Y2 receptor-mediated mossy fiber plasticity is implicated in nicotine abstinence-related social anxiety-like behavior in an outbred rat model of the novelty-seeking phenotype

Limbic but not non-limbic kindling impairs conditioned fear and promotes plasticity of NPY and its Y2 receptor

Intravenous Immunoglobulin Reduces Tau Pathology and Preserves Neuroplastic Gene Expression in the 3xTg Mouse Model of Alzheimer’s Disease

Transplantation of Neural Stem Cells Clonally Derived from Embryonic Stem Cells Promotes Recovery of the Injured Mouse Spinal Cord

Fgfr1 Inactivation in the Mouse Telencephalon Results in Impaired Maturation of Interneurons Expressing Parvalbumin

Spinal Cord Injury Causes Brain Inflammation Associated with Cognitive and Affective Changes: Role of Cell Cycle Pathways

Neuropathology of the Anterior Midcingulate Cortex in Young Children With Autism.

BAG1 is Neuroprotective in In Vivo and In Vitro Models of Parkinson’s Disease

star Sociosexual and Communication Deficits after Traumatic Injury to the Developing Murine Brain

Hepatoprotective Effects of B-1,3-(D)-Glucan on Bortezomib-Induced Liver Damage in Rats

Analysis in conditional cannabinoid 1 receptor-knockout mice reveals neuronal subpopulation-specific effects on epileptogenesis in the kindling paradigm

Novel mGluR5 Positive Allosteric Modulator Improves Functional Recovery, Attenuates Neurodegeneration, and Alters Microglial Polarization after Experimental Traumatic Brain Injury

 

Recommended Stereology Workshops and Courses

NeuroStereology Workshop

Organized by Professor Mark West
November 13-14, 2014
The Westin Washington, D.C. City Center
Washington, D.C. (USA)

Short Description
The goal of the workshop is to teach a small group of research scientists how to design, supervise, and critically evaluate stereological studies of the nervous system. Stereology is a methodology that provides meaningful quantitative descriptions of the geometry of three-dimensional structures from measurements that are made on two-dimensional images sampled from a structure of interest. The workshop will emphasize modern ”design based” stereology, which is characterized by the preparation and probing of tissue in such a manner that no assumptions about the size, shape, and orientation of the structures being quantified are necessary.

The target audience includes neuroscience research scientists working at the graduate student, post-doctoral, and senior scientists who are interested in the practical application of design based stereological methods. The number of participants will be limited to 30, to ensure robust faculty-student interaction.

 

Note: MBF Bioscience only recommends courses and workshops taught by capable and qualified instructors with no commercial affiliations.

 

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Sponsored by MBF Bioscience
developers of Stereo Investigator, the world’s most cited stereology system