The Most Comprehensive Source of Stereology Information on the Web


What is, the Stereology Information Center, includes a wide range of knowledge about stereology. This site introduces both basic and advanced concepts in the field. The emphasis is on its use in biological research, though anyone interested in learning concepts of stereology will find something of interest. The application of stereological methods to biological studies permits researchers to effectively and efficiently gather data. This site is dedicated to helping researchers understand the principles of design-based stereology and its advantages over less sophisticated approaches in quantitative histology.

Design-based stereology is a set of methods to ensure rigorous quantitative analysis of the size, shape, and number of objects. When properly used, stereology plays an important role in validating and rejecting experimental hypotheses in biological research. It produces results that are unbiased, efficient, and more reliable than other ad hoc quantitative analyses. Unbiased stereology provides an important contribution to the advancement in biological research by improving the consistency and dependability of quantitative analytical results produced in the laboratory and reported in scientific publications.

The Counting Frame is a fundamental tool in stereological research.

Recent Noteworthy Stereology Publications

Published papers using Stereology; last updated on 07/17/2014, * indicates an example where a good job was done reporting stereological parameters

Different reactions to irradiation in the juvenile and adult hippocampus

Enhancement of Neuroblast Migration into the Injured Cerebral Cortex using Laminin-containing Porous Sponge

Differential distribution of hypoxia-inducible factor 1-beta (ARNT or ARNT2) in mouse substantia nigra and ventral tegmental area

Reducing C-Terminal-Truncated Alpha-Synuclein by Immunotherapy Attenuates Neurodegeneration and Propagation in Parkinson’s Disease-Like Models

The comparison of the viability of crushed, morselized and diced cartilage grafts: a confocal microscopic study

Altered selenium status in Huntington’s disease: Neuroprotection by selenite in the N171-82Q mouse model

Influenza vaccination during early pregnancy contributes to neurogenesis and behavioral function in offspring

Stage-dependent nigral neuronal loss in incidental Lewy body and Parkinson’s disease

Functional correlates of central white matter maturation in perinatal period in rabbits

Maintenance of bladder innervation in diabetes: A stereological study of streptozotocin-treated female rats

FGF/FGFR2 Signaling Regulates the Generation and Correct Positioning of Bergmann Glia Cells in the Developing Mouse Cerebellum

Intrastriatal GDNF gene transfer by inducible lentivirus vectors protects dopaminergic neurons in a rat model of parkinsonism

Low Dose Prenatal Alcohol Exposure Does Not Impair Spatial Learning and Memory in Two Tests in Adult and Aged Rats

A clinically relevant animal model of TMD and IBS co-morbidity

Cannabinoid receptor CB2 is expressed on vascular cells, but not astroglial cells in the post-mortem human Huntington’s disease brain

Distribution and morphological characteristics of striatal interneurons expressing calretinin in mice: A comparison with human and nonhuman primates

Fluoxetine treatment ameliorates depression induced by perinatal arsenic exposure via a neurogenic mechanism

Endovascular perforation subarachnoid hemorrhage fails to cause Morris water maze deficits in the mouse

Inhaled budesonide protects against chronic asthma-induced neuroinflammation in mouse brain

Bilateral Contusion-Compression Model of Incomplete Traumatic Cervical Spinal Cord Injury (SCI)

Silencing of murine transthyretin and retinol binding protein genes have distinct and shared behavioral and neuropathologic effects

The cholinergic basal forebrain in the ferret and its inputs to the auditory cortex

Prenatal Infection Affects the Neuronal Architecture and Cognitive Function in Adult Mice

The effect of spaceflight on mouse olfactory bulb volume, neurogenesis, and cell death indicates the protective effect of novel environment

Optimizing atoh1-induced vestibular hair cell regeneration


Recommended Stereology Workshops and Courses


Organized by Dr. Daniel Peterson
August 18-22, 2014
Chicago, IL (USA)

Practical Workshops in Confocal Microscopy and Design-Based Stereology

Short Description
The purpose of this intensive, week-long workshop is to provide a comprehensive background in the theory and practice of modern histological preparation and microscopic analysis for researchers in biomedical science. The workshop provides a practical tutorial in all aspects of microscopic analysis including experimental design, specimen preparation, use of fluorescence and confocal microscopes, design-based stereology, and image preparation for scientific publication. A variety of microscopes equipped for stereology are available for use. Participants should bring examples of their material and problems for discussion. In addition to lectures, substantial time is devoted to “hands-on” practical sessions. Attendees participate in group discussion, where they can discuss their research applications and consult with the instructors.


Organized by Professor Mark West
November 13-14, 2014
The Westin Washington, D.C. City Center
Washington, D.C. (USA)

NeuroStereology Workshop

Short Description
The goal of the workshop is to teach a small group of research scientists how to design, supervise, and critically evaluate stereological studies of the nervous system. Stereology is a methodology that provides meaningful quantitative descriptions of the geometry of three-dimensional structures from measurements that are made on two-dimensional images sampled from a structure of interest. The workshop will emphasize modern ”design based” stereology, which is characterized by the preparation and probing of tissue in such a manner that no assumptions about the size, shape, and orientation of the structures being quantified are necessary.

The target audience includes neuroscience research scientists working at the graduate student, post-doctoral, and senior scientists who are interested in the practical application of design based stereological methods. The number of participants will be limited to 30, to ensure robust faculty-student interaction.


NotePlease note that MBF Bioscience only recommends courses and workshops taught by capable and qualified instructors with no commercial affiliations.