The Most Comprehensive Source of Stereology Information on the Web

Stereology Information for the Biological Sciences

This site introduces both basic and advanced concepts of Stereology. The emphasis is on the use of stereology in biological research, though anyone interested in learning concepts of stereology will find something of interest. The application of stereological methods to biological studies permits researchers to effectively and efficiently gather unbiased, accurate data. This site is dedicated to helping researchers understand the principles of design-based stereology and its advantages over less sophisticated approaches in quantitative histology. Design-based stereology is a set of methods to ensure rigorous quantitative analysis of the size, shape, and number of objects. When properly used, stereology plays an important role in validating and rejecting experimental hypotheses in biological research. It produces results that are unbiased, efficient, and more reliable than other ad hoc quantitative analyses. Unbiased stereology provides an important contribution to the advancement in biological research by improving the consistency and dependability of quantitative analytical results produced in the laboratory and reported in scientific publications. The Counting Frame is a fundamental tool in stereological research.

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Satellite Symposium at SfN: Enhancing the Reproducibility of Your Research Results with Stereology

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Recent headlines decry the alarming amount of irreproducible data in published research papers. MBF Bioscience is hosting a symposium addressing the topic on Sunday, October 18 at 6:30pm entitled “Quantitative Microscopy: Enhancing the Reproducibility of Your Research Results with Stereology.” This symposium, which is a satellite event at the annual Society for Neuroscience meeting, will address how researchers can use stereology to obtain accurate, reproducible data about their histological tissue specimens to drive meaningful discovery by the scientific community at large.

It will be an evening full of engaging speakers with significant expertise in various aspects of stereology, including: stereology theory, the application of stereology in neuroscience research, and why some funding agencies require stereology. Attendees will have a chance to interact with the speakers during the question and answer session following the presentations.

Stereology is the gold standard method for quantifying the number of cells, length of fibers, and the area and volume of structures or regions in tissue specimens. Attend this symposium to learn how it can help you obtain accurate, reproducible data for your research study.

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Recent peer-reviewed publications show that Stereo Investigator continues to be the leading stereology system

In 2014 researchers used Stereo Investigator in 698 peer-reviewed papers – citing it nearly three times more than all other stereology systems combined. These researchers often tell us the reasons Stereo Investigator continues to be the most widely used system for unbiased stereology are:

  1. It has sophisticated integration with all research microscopes and nearly all imaging technologies
  2. It provides repeatable, unbiased data about neuron populations and regions of interest
  3. The reliable and knowledgeable technical support and research expertise provided by MBF Bioscience
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source: google scholar

Professor Mark J. West, co-developer of the Optical Fractionator stereology probe and Professor of Medical Neurobiology at Aarhus University in Denmark, says “Stereo Investigator is the most reliable tool for collecting unbiased stereology data. It’s backed by excellent technical and research support teams at MBF – you can call to ask about stereology probes, tissue preparation, microscope hardware, basically anything regarding your stereology study.”

Continue reading “2014: An outstanding year for Stereo Investigator” »

 

Recent Noteworthy Stereology Publications

Published papers using unbiased stereology; last updated on 07/20/2015.

starindicates that the researchers did an especially good job reporting stereological parameters.

Visual Specializations in Five Sympatric Species of Stingrays from the Family Dasyatidae

Fas-associated factor 1 promotes in neurofibrillary tangle-mediated cell death of basal forebrain cholinergic neurons in P301L transgenic mice.

Altered visual processing in a rodent model of Attention-Deficit Hyperactivity Disorder

Effects of Diabetes on Post-Menopausal Rat Submandibular Glands: A Histopathological and Stereological Examination

Lesion of medulla’s catecholaminergic neurons is associated with cardiovascular dysfunction in rotenone-induced Parkinson’s disease rats

Got worms? Perinatal exposure to helminths prevents persistent immune sensitization and cognitive dysfunction induced by early-life infection

Nrf2-ARE signals mediated the anti-oxidative action of electro-acupuncture in an MPTP mouse model of Parkinson’s disease

Metabolic changes in early poststatus epilepticus measured by MR spectroscopy in rats

Limitations of in vivo reprogramming to dopaminergic neurons via a tricistronic strategy

Thermoresponsive Copolypeptide Hydrogel Vehicles for Central Nervous System Cell Delivery

 

Continue reading “Recent Noteworthy Stereology publications”

 

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Sponsored by MBF Bioscience developers of Stereo Investigator, the world’s most cited stereology system