The Most Comprehensive Source of Stereology Information on the Web

Stereology Information for the Biological Sciences

This site introduces both basic and advanced concepts of Stereology. The emphasis is on the use of stereology in biological research, though anyone interested in learning concepts of stereology will find something of interest. The application of stereological methods to biological studies permits researchers to effectively and efficiently gather unbiased, accurate data. This site is dedicated to helping researchers understand the principles of design-based stereology and its advantages over less sophisticated approaches in quantitative histology. Design-based stereology is a set of methods to ensure rigorous quantitative analysis of the size, shape, and number of objects. When properly used, stereology plays an important role in validating and rejecting experimental hypotheses in biological research. It produces results that are unbiased, efficient, and more reliable than other ad hoc quantitative analyses. Unbiased stereology provides an important contribution to the advancement in biological research by improving the consistency and dependability of quantitative analytical results produced in the laboratory and reported in scientific publications.

*Use the side navigation bar or the top navigation bar to browse the site.The Counting Frame is a fundamental tool in stereological research.

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Recent Stereology News

Recent peer-reviewed publications show that Stereo Investigator continues to be the leading stereology system

In 2014 researchers used Stereo Investigator in 698 peer-reviewed papers – citing it nearly three times more than all other stereology systems combined. These researchers often tell us the reasons Stereo Investigator continues to be the most widely used system for unbiased stereology are:

  1. It has sophisticated integration with all research microscopes and nearly all imaging technologies
  2. It provides repeatable, unbiased data about neuron populations and regions of interest
  3. The reliable and knowledgeable technical support and research expertise provided by MBF Bioscience
source: google scholar

Professor Mark J. West, co-developer of the Optical Fractionator stereology probe and Professor of Medical Neurobiology at Aarhus University in Denmark, says “Stereo Investigator is the most reliable tool for collecting unbiased stereology data. It’s backed by excellent technical and research support teams at MBF – you can call to ask about stereology probes, tissue preparation, microscope hardware, basically anything regarding your stereology study.”

Continue reading “2014: An outstanding year for Stereo Investigator” »

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Recent Noteworthy Stereology Publications

Published papers using unbiased stereology; last updated on 11/13/2015.

starindicates that the researchers did an especially good job reporting stereological parameters.

A Novel Closed-head Model of Mild Traumatic Brain Injury using Focal Primary Overpressure Blast to the Cranium in Mice

Bone Marrow Stromal Cell Intraspinal Transplants Fail to Improve Motor Outcomes in a Severe Model of Spinal Cord Injury

Deficits in hippocampal-dependent transfer generalization learning accompany synaptic dysfunction in a mouse model of amyloidosis

Novel rat model of weight drop-induced closed diffuse traumatic brain injury compatible with electrophysiological recordings of vigilance states

Pre-differentiation of human neural stem cells into GABAergic neurons prior to transplant results in greater repopulation of the damaged brain and accelerates functional recovery after transient ischemic stroke

Area postrema undergoes dynamic postnatal changes in mice and humans

Maternal Iron Deficiency Worsens the Associative Learning Deficits and Hippocampal and Cerebellar Losses in a Rat Model of Fetal Alcohol Spectrum Disorders


MPTP-induced executive dysfunction is associated with altered prefrontal serotonergic function

Riluzole promotes motor and respiratory recovery associated with enhanced neuronal survival and function following high cervical spinal hemisection

Maternal exposure to a continuous 900-MHz electromagnetic field provokes neuronal loss and pathological changes in cerebellum of 32-day-old female rat offspring

Prior regular exercise improves clinical outcome and reduces demyelination and axonal injury in experimental autoimmune encephalomyelitis



Continue reading “Recent Noteworthy Stereology publications”

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Sponsored by MBF Bioscience
developers of Stereo Investigator, the world’s most cited stereology system 

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