What is Stereology.info?
Stereology.info, the Stereology Information Center, includes a wide range of knowledge about stereology. This site introduces both basic and advanced concepts in the field. The emphasis is on its use in biological research, though anyone interested in learning concepts of stereology will find something of interest. The application of stereological methods to biological studies permits researchers to effectively and efficiently gather data. This site is dedicated to helping researchers understand the principles of design-based stereology and its advantages over less sophisticated approaches in quantitative histology.
Design-based stereology is a set of methods to ensure rigorous quantitative analysis of the size, shape, and number of objects. When properly used, stereology plays an important role in validating and rejecting experimental hypotheses in biological research. It produces results that are unbiased, efficient, and more reliable than other ad hoc quantitative analyses. Unbiased stereology provides an important contribution to the advancement in biological research by improving the consistency and dependability of quantitative analytical results produced in the laboratory and reported in scientific publications.
Recent Noteworthy Stereology Publications
Published papers using stereology; last updated on 10/03/2014, indicates that the researchers did an exemplary job reporting stereological parameters
Astrocytes show reduced support of motor neurons with aging that is accelerated in a rodent model of ALS
Neuroprotective effects of aldehyde dehydrogenase 2 activation in rotenone-induced cellular and animal models of parkinsonism
Methamphetamine affects cell proliferation in the medial prefrontal cortex: A new niche for toxicity
Deficit in sustained attention following selective cholinergic lesion of the pedunculopontine tegmental nucleus in rat, as measured with both post-mortem immunocytochemistry and in vivo PET imaging with [18F]fluoroethoxybenzovesamicol
Alpha-synuclein as a Pathological Link between Chronic Traumatic Brain Injury and Parkinson’s disease
Cux2 activity defines a subpopulation of perinatal neurogenic progenitors in the hippocampus
Nonclinical evaluation of CNS-administered TPP1 enzyme replacement in canine CLN2 neuronal ceroid lipofuscinosis
Chronic decrease in wakefulness and disruption of sleep-wake behavior after experimental traumatic brain injury
Stereological study of the neuronal number and volume of 38 brain subdivisions of subjects diagnosed with autism reveals significant alterations restricted to the striatum, amygdalaand cerebellum
Blockade of excitatory synaptogenesis with proximal dendrites of dentate granule cells following rapamycin treatment in a mouse model of temporal lobe epilepsy
Survival of Neural Stem Cell Grafts in the Lesioned Spinal Cord Is Enhanced by a Combination of Treadmill Locomotor Training via Insulin-Like Growth Factor-1 Signaling
Deficiency of Trim27 protects dopaminergic neurons from apoptosis in the neurotoxin model of Parkinson׳s disease
Adenosine kinase, glutamine synthetase and EAAT2 as gene therapy targets for temporal lobe epilepsy
Highly potent soluble amyloid-β seeds in human Alzheimer brain but not cerebrospinal fluid
Neonatal onset of leptin signaling in dopamine neurons of the ventral tegmental area in the rat
Wild-type bone marrow transplant partially reverses neuroinflammation in progranulin-deficient mice
Intravenous immunoglobulin G improves neurobehavioral and histological outcomes after traumatic brain injury in mice
Conditional Deletion of α-CaMKII Impairs Integration of Adult-Generated Granule Cells into Dentate Gyrus Circuits and Hippocampus-Dependent Learning
Early Expression of Hypocretin/Orexin in the Chick Embryo Brain
Cannabinoid CB2 receptor (CB2R) stimulation delays rubrospinal mitochondrial-dependent degeneration and improves functional recovery after spinal cord hemisection by ERK1/2 inactivation
Regulation of fibroblast lipid-storage and myofibroblast phenotypes during alveolar septation in mice
Hippocampal Y2 receptor-mediated mossy fiber plasticity is implicated in nicotine abstinence-related social anxiety-like behavior in an outbred rat model of the novelty-seeking phenotype
Limbic but not non-limbic kindling impairs conditioned fear and promotes plasticity of NPY and its Y2 receptor
Intravenous Immunoglobulin Reduces Tau Pathology and Preserves Neuroplastic Gene Expression in the 3xTg Mouse Model of Alzheimer’s Disease
Transplantation of Neural Stem Cells Clonally Derived from Embryonic Stem Cells Promotes Recovery of the Injured Mouse Spinal Cord
Fgfr1 Inactivation in the Mouse Telencephalon Results in Impaired Maturation of Interneurons Expressing Parvalbumin
Spinal Cord Injury Causes Brain Inflammation Associated with Cognitive and Affective Changes: Role of Cell Cycle Pathways
Neuropathology of the Anterior Midcingulate Cortex in Young Children With Autism.
BAG1 is Neuroprotective in In Vivo and In Vitro Models of Parkinson’s Disease
Sociosexual and Communication Deficits after Traumatic Injury to the Developing Murine Brain
Hepatoprotective Effects of B-1,3-(D)-Glucan on Bortezomib-Induced Liver Damage in Rats
Analysis in conditional cannabinoid 1 receptor-knockout mice reveals neuronal subpopulation-specific effects on epileptogenesis in the kindling paradigm
Novel mGluR5 Positive Allosteric Modulator Improves Functional Recovery, Attenuates Neurodegeneration, and Alters Microglial Polarization after Experimental Traumatic Brain Injury
Recommended Stereology Workshops and Courses
Organized by Professor Mark West
November 13-14, 2014
The Westin Washington, D.C. City Center
Washington, D.C. (USA)
The goal of the workshop is to teach a small group of research scientists how to design, supervise, and critically evaluate stereological studies of the nervous system. Stereology is a methodology that provides meaningful quantitative descriptions of the geometry of three-dimensional structures from measurements that are made on two-dimensional images sampled from a structure of interest. The workshop will emphasize modern ”design based” stereology, which is characterized by the preparation and probing of tissue in such a manner that no assumptions about the size, shape, and orientation of the structures being quantified are necessary.
The target audience includes neuroscience research scientists working at the graduate student, post-doctoral, and senior scientists who are interested in the practical application of design based stereological methods. The number of participants will be limited to 30, to ensure robust faculty-student interaction.
Note: MBF Bioscience only recommends courses and workshops taught by capable and qualified instructors with no commercial affiliations.
Sponsored by MBF Bioscience
developers of Stereo Investigator, the world’s most cited stereology system