The Most Comprehensive Source of Stereology Information on the Web


What is, the Stereology Information Center, includes a wide range of knowledge about stereology. This site introduces both basic and advanced concepts in the field. The emphasis is on its use in biological research, though anyone interested in learning concepts of stereology will find something of interest. The application of stereological methods to biological studies permits researchers to effectively and efficiently gather data. This site is dedicated to helping researchers understand the principles of design-based stereology and its advantages over less sophisticated approaches in quantitative histology.

Design-based stereology is a set of methods to ensure rigorous quantitative analysis of the size, shape, and number of objects. When properly used, stereology plays an important role in validating and rejecting experimental hypotheses in biological research. It produces results that are unbiased, efficient, and more reliable than other ad hoc quantitative analyses. Unbiased stereology provides an important contribution to the advancement in biological research by improving the consistency and dependability of quantitative analytical results produced in the laboratory and reported in scientific publications.

The Counting Frame is a fundamental tool in stereological research.

Recent Noteworthy Stereology Publications

Published papers using Stereology; last updated on 08/20/2014, * indicates an example where a good job was done reporting stereological parameters

Transplantation of Neural Stem Cells Clonally Derived from Embryonic Stem Cells Promotes Recovery of the Injured Mouse Spinal Cord

Fgfr1 Inactivation in the Mouse Telencephalon Results in Impaired Maturation of Interneurons Expressing Parvalbumin

Spinal Cord Injury Causes Brain Inflammation Associated with Cognitive and Affective Changes: Role of Cell Cycle Pathways

Neuropathology of the Anterior Midcingulate Cortex in Young Children With Autism.

BAG1 is Neuroprotective in In Vivo and In Vitro Models of Parkinson’s Disease

Sociosexual and Communication Deficits after Traumatic Injury to the Developing Murine Brain *

Hepatoprotective Effects of B-1,3-(D)-Glucan on Bortezomib-Induced Liver Damage in Rats

Analysis in conditional cannabinoid 1 receptor-knockout mice reveals neuronal subpopulation-specific effects on epileptogenesis in the kindling paradigm

Novel mGluR5 Positive Allosteric Modulator Improves Functional Recovery, Attenuates Neurodegeneration, and Alters Microglial Polarization after Experimental Traumatic Brain Injury

(G2019S) LRRK2 causes early-phase dysfunction of SNpc dopaminergic neurons and impairment of corticostriatal long-term depression in the PD transgenic mouse

The capsaicin receptor TRPV1 as a novel modulator of neural precursor cell proliferation

Multiple Factors Contribute to the Peripheral Induction of Cerebral β-Amyloidosis

Effects of prenatal 900 MHz electromagnetic field exposures on the histology of rat kidney

Characterization of the role of adult neurogenesis in touch-screen discrimination learning

Investigation of the effect of telmisartan on experimentally induced peripheral nerve injury in rats

RELN-expressing neuron density in layer I of the superior temporal lobe is similar in human brains with autism and in age-matched controls

A cognitive rehabilitation paradigm effective in male rats lacks efficacy in female rats

Downregulation of miR-23a and miR-27a following Experimental Traumatic Brain Injury Induces Neuronal Cell Death through Activation of Proapoptotic Bcl-2 Proteins

Rehabilitative Training Promotes Rapid Motor Recovery but Delayed Motor Map Reorganization in a Rat Cortical Ischemic Infarct Model

Selective increase of in vivo firing frequencies in DA SN neurons after proteasome inhibition in the ventral midbrain

Poly(lactic-co-glycolic) acid microspheres encapsulated in Pluronic F-127 prolong hirudin delivery and improve functional recovery from a demyelination lesion


Reduced GABAergic Inhibition in the Basolateral Amygdala and the Development of Anxiety-Like Behaviors after Mild Traumatic Brain Injury *

Cerebrolysin™ efficacy in a transgenic model of tauopathy: role in regulation of mitochondrial structure *

Ataxia and Purkinje cell degeneration in mice lacking the CAMTA1 transcription factor

Treatment with α-lipoic acid enhances the bone healing after femoral fracture model of rats

The role of the area postrema in the anorectic effects of amylin and salmon calcitonin: behavioral and neuronal phenotyping

Enhancing Astrocytic Lysosome Biogenesis Facilitates Aβ Clearance and Attenuates Amyloid Plaque Pathogenesis

Heterozygous deletion of the Williams-Beuren syndrome critical interval in mice recapitulates most features of the human disorder

Remodeling of the piriform cortex after lesion in adult rodents.

Different reactions to irradiation in the juvenile and adult hippocampus

Enhancement of Neuroblast Migration into the Injured Cerebral Cortex using Laminin-containing Porous Sponge

Differential distribution of hypoxia-inducible factor 1-beta (ARNT or ARNT2) in mouse substantia nigra and ventral tegmental area

Reducing C-Terminal-Truncated Alpha-Synuclein by Immunotherapy Attenuates Neurodegeneration and Propagation in Parkinson’s Disease-Like Models

The comparison of the viability of crushed, morselized and diced cartilage grafts: a confocal microscopic study

Altered selenium status in Huntington’s disease: Neuroprotection by selenite in the N171-82Q mouse model

Influenza vaccination during early pregnancy contributes to neurogenesis and behavioral function in offspring

Stage-dependent nigral neuronal loss in incidental Lewy body and Parkinson’s disease

Functional correlates of central white matter maturation in perinatal period in rabbits

Maintenance of bladder innervation in diabetes: A stereological study of streptozotocin-treated female rats

FGF/FGFR2 Signaling Regulates the Generation and Correct Positioning of Bergmann Glia Cells in the Developing Mouse Cerebellum

Recommended Stereology Workshops and Courses

Iowa Microscopy Society Meeting
September 26, 2014
University of Iowa
Iowa City, Iowa (USA)

Organizer: Dr. Julie Korich

Dr. Julie Korich, Staff Scientist, will be presenting at the annual  Iowa Microscopy Society meeting. Her talk is titled “Using Design Based Stereology in Scientific Studies” The presentation will focus on real world examples of using design-based stereology in research studies.


NeuroStereology Workshop

Organized by Professor Mark West
November 13-14, 2014
The Westin Washington, D.C. City Center
Washington, D.C. (USA)

Short Description
The goal of the workshop is to teach a small group of research scientists how to design, supervise, and critically evaluate stereological studies of the nervous system. Stereology is a methodology that provides meaningful quantitative descriptions of the geometry of three-dimensional structures from measurements that are made on two-dimensional images sampled from a structure of interest. The workshop will emphasize modern ”design based” stereology, which is characterized by the preparation and probing of tissue in such a manner that no assumptions about the size, shape, and orientation of the structures being quantified are necessary.

The target audience includes neuroscience research scientists working at the graduate student, post-doctoral, and senior scientists who are interested in the practical application of design based stereological methods. The number of participants will be limited to 30, to ensure robust faculty-student interaction.


Note: MBF Bioscience only recommends courses and workshops taught by capable and qualified instructors with no commercial affiliations.



Sponsored by MBF Bioscience
developers of Stereo Investigator, the world’s most cited stereology system