The Most Comprehensive Source of Stereology Information on the Web

What is Stereology.info?

Stereology.info includes a wide range of knowledge about stereology. This site introduces both basic and advanced concepts in the field. The emphasis is on its use in biological research, though anyone interested in learning concepts of stereology will find something of interest. The application of stereological methods to biological studies permits researchers to effectively and efficiently gather data. This site is dedicated to helping researchers understand the principles of design-based stereology and its advantages over less sophisticated approaches in quantitative histology.

Design-based stereology is a set of methods to ensure rigorous quantitative analysis of the size, shape, and number of objects. When properly used, stereology plays an important role in validating and rejecting experimental hypotheses in biological research. It produces results that are unbiased, efficient, and more reliable than other ad hoc quantitative analyses. Unbiased stereology provides an important contribution to the advancement in biological research by improving the consistency and dependability of quantitative analytical results produced in the laboratory and reported in scientific publications.

The Counting Frame is a fundamental tool in stereological research.

Stereo Investigator continues to be the leading stereology system

In 2014 researchers used Stereo Investigator in 698 peer-reviewed papers – citing it nearly three times as all other stereology systems combined. These researchers tell us the reasons it continues to be the most widely used system for unbiased stereology are:

  1. it works with many different microscopes and imaging technologies
  2. it provides unbiased data about neuron populations and regions of interest
  3. of the with strong technical and research support provided by MBF Bioscience
2014
source: google scholar

Dr. Mark West, co-developer of the Optical Fractionator stereology probe and Professor of Medical Neurobiology at Aarhus University in Denmark, says “Stereo Investigator is the most reliable tool for collecting unbiased stereology data. It’s backed by excellent technical and research support teams at MBF – you can call to ask about stereology probes, tissue preparation, microscope hardware, basically anything regarding your stereology study.”

Continue reading “2014: An outstanding year for Stereo Investigator” »

 

Recent Noteworthy Stereology Publications

Published papers using unbiased stereology; last updated on 04/16/2014.

starindicates that the researchers did a good job reporting stereological parameters.

Small Peptide Inhibitor of JNK3 Protects Dopaminergic Neurons from MPTP Induced Injury via Inhibiting the ASK1-JNK3 Signaling Pathway

Cerebrovascular and blood–brain barrier impairments in Huntington’s disease: Potential implications for its pathophysiology

Continuous High-Frequency Stimulation of the Subthalamic Nucleus Improves Cell Survival and Functional Recovery Following Dopaminergic Cell Transplantation in Rodents

Striatal tyrosine hydroxylase-positive neurons are associated with l-DOPA-induced dyskinesia in hemiparkinsonian mice

Erythropoietin-mediated neuroprotection in a pediatric mouse model of chronic hypoxia

Postnatal Loss of Hap1 Reduces Hippocampal Neurogenesis and Causes Adult Depressive-Like Behavior in Mice

Convergence of lemniscal and local excitatory inputs on large gabaergic tectothalamic neurons

starThe impact of slaughter age on performance, carcass traits, properties of cutup pieces of carcasses, and muscle development in broiler chickens

Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock in mice

Guanidinylated block copolymers for gene transfer: A comparison with amine-based materials for in vitro and in vivo gene transfer efficiency

Serum- glucocorticoid-inducible kinase 1 confers protection in cell-based and in in vivo neurotoxin models via the c-Jun N-terminal kinase signaling pathway

Hypoxic preconditioning can reduce injury-induced inflammatory processes in the neonatal rat brain

A Nurr1 Agonist Causes Neuroprotection in a Parkinson’s Disease Lesion Model Primed with the Toll-Like Receptor 3 dsRNA Inflammatory Stimulant Poly(I:C)

starA Novel Triple Repeat Mutant Tau Transgenic Model That Mimics Aspects of Pick’s Disease and Fronto-Temporal Tauopathies

The Type 3 Adenylyl Cyclase Is Required for the Survival and Maturation of Newly Generated Granule Cells in the Olfactory Bulb

Stereological estimation of neuron number and plaque load in the hippocampal region of a transgenic rat model of Alzheimer’s disease

Cross-Recognition of a Myelin Peptide by CD8+ T Cells in the CNS Is Not Sufficient to Promote Neuronal Damage

Lack of exacerbation of neurodegeneration in a double transgenic mouse model of mutant LRRK2 and tau

Therapeutic Effects of Melatonin on Alveolar Bone Resorption After Experimental Periodontitis in Rats. A Biochemical and Immunohistochemical Study

Neuron-to-neuron α-synuclein propagation in vivo is independent of neuronal injury

Activation of CNTF/CNTFRα Signaling Pathway by hRheb(S16H) Transduction of Dopaminergic Neurons In Vivo

Arc expression identifies the lateral amygdala fear memory trace

Neuroprotective Effects of Oligodendrocyte Progenitor Cell Transplantation in Premature Rat Brain following Hypoxic-Ischemic Injury

Adult emotionality and neural plasticity as a function of adolescent nutrient supplementation in male rats

Dissociation in the Effects of Induced Neonatal Hypoxia-Ischemia on Rapid Auditory Processing and Spatial Working Memory in Male Rats

Enhancing Hippocampal Neuronal Numbers in Morphine-Dependent Rats by Voluntary Exercise Through a Brain-Derived Neurotrophic Factor-Mediated Mechanism

Intraneuronal accumulation of misfolded tau protein induces overexpression of Hsp27 in activated astrocytes

Forebrain neuronal specific ablation of p53 gene provides protection in a cortical ischemic stroke model

starThe influence of aging on the number of neurons and levels of non-phosporylated neurofilament proteins in the central auditory system of rats

Developmental Trajectories of Auditory Cortex Synaptic Structures and Gap-Prepulse Inhibition of Acoustic Startle Between Early Adolescence and Young Adulthood in Mice

Maternal vitamin D deficiency alters fetal brain development in the BALB/c mouse

A stereological analysis of NPY, POMC, orexin, GFAP astrocyte and Iba1 microglia cell number and volume in diet-induced obese male mice

Impaired Leptomeningeal Collateral Flow Contributes to the Poor Outcome following Experimental Stroke in the Type 2 Diabetic Mice

The Loss of Glucose Regulated Protein 78 (GRP78) during Normal Aging or from siRNA Knockdown Augments Human Alpha-Synuclein (α-syn) Toxicity to Rat Nigral Neurons

C–C chemokine receptor type 2 (CCR2) signaling protects neonatal male mice with hypoxic–ischemic hippocampal damage from developing spatial learning deficits

Amitriptyline Improves Motor Function via Enhanced Neurotrophin Signaling and Mitochondrial Functions in the Murine N171-82Q Huntington’s Disease Model

Maternal Inflammation Contributes to Brain Overgrowth and Autism-Associated Behaviors through Altered Redox Signaling in Stem and Progenitor Cells

Specific Amyloid β Clearance by a Catalytic Antibody Construct

starDonepezil Rescues Spatial Learning and Memory Deficits following Traumatic Brain Injury Independent of Its Effects on Neurogenesis

Chondroitin Sulfate Proteoglycans Negatively Modulate Spinal Cord Neural Precursor Cells by Signaling through LAR and RPTPσ and modulation of the Rho/ROCK Pathway

Inhibition of 14-3-3 Proteins Leads to Schizophrenia-Related Behavioral Phenotypes and Synaptic Defects in Mice

Gene Dosage Dependent Aggravation of the Neurological Phenotype in the 5XFAD Mouse Model of Alzheimer’s Disease

Automated High Performance Analysis of Lung Morphometry

Near infrared light mitigates cerebellar pathology in transgenic mouse models of dementia

Masculinization of the Zebra Finch Song System: Roles of Oestradiol and the Z-chromosome Gene Tubulin Specific Chaperone Protein A

Protection from cyanide-induced brain injury by the Nrf2 transcriptional activator carnosic acid

αCaMKII autophosphorylation mediates neuronal activation in the hippocampal dentate gyrus after alcohol and cocaine in mice

A rat model of nerve agent exposure applicable to the pediatric population: The anticonvulsant efficacies of atropine and GluK1 antagonists

starA partial lesion model of Parkinson’s disease in mice – Characterization of a 6-OHDA-induced medial forebrain bundle lesion

Administration of Umbilical Cord Blood Cells Transiently Decreased Hypoxic-Ischemic Brain Injury in Neonatal Rats

Imipramine protects against the deleterious effects of chronic corticosterone on depression-like behavior, hippocampal reelin expression, and neuronal maturation

Mitotic events in cerebellar granule progenitor cells that expand cerebellar surface area are critical for normal cerebellar cortical lamination in mice.

Chronic P7C3 treatment restores hippocampal neurogenesis

Neonatal iron supplementation potentiates oxidative stress, energetic dysfunction and neurodegeneration in the R6/2 mouse model of Huntington’s disease

starGlucose and oxygen metabolism after penetrating ballistic-like brain injury

Continue reading “Recent Noteworthy Stereology publications”

 

 

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developers of Stereo Investigator, the world’s most cited stereology system