The Most Comprehensive Source of Stereology Information on the Web

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Stereology Information for the Biological Sciences

This site introduces both basic and advanced concepts of Stereology. The emphasis is on the use of stereology in biological research, though anyone interested in learning concepts of stereology will find something of interest. The application of stereological methods to biological studies permits researchers to effectively and efficiently gather unbiased, accurate data. This site is dedicated to helping researchers understand the principles of design-based stereology and its advantages over less sophisticated approaches in quantitative histology. Design-based stereology is a set of methods to ensure rigorous quantitative analysis of the size, shape, and number of objects. When properly used, stereology plays an important role in validating and rejecting experimental hypotheses in biological research. It produces results that are unbiased, efficient, and more reliable than other ad hoc quantitative analyses. Unbiased stereology provides an important contribution to the advancement in biological research by improving the consistency and dependability of quantitative analytical results produced in the laboratory and reported in scientific publications.

*Use the side navigation bar or the top navigation bar to browse the site.The Counting Frame is a fundamental tool in stereological research.

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Recent Stereology News

Recent peer-reviewed publications show that Stereo Investigator continues to be the leading stereology system

In 2014 researchers used Stereo Investigator in 698 peer-reviewed papers – citing it nearly three times more than all other stereology systems combined. These researchers often tell us the reasons Stereo Investigator continues to be the most widely used system for unbiased stereology are:

  1. It has sophisticated integration with all research microscopes and nearly all imaging technologies
  2. It provides repeatable, unbiased data about neuron populations and regions of interest
  3. The reliable and knowledgeable technical support and research expertise provided by MBF Bioscience
2014
source: google scholar

Professor Mark J. West, co-developer of the Optical Fractionator stereology probe and Professor of Medical Neurobiology at Aarhus University in Denmark, says “Stereo Investigator is the most reliable tool for collecting unbiased stereology data. It’s backed by excellent technical and research support teams at MBF – you can call to ask about stereology probes, tissue preparation, microscope hardware, basically anything regarding your stereology study.”

Continue reading “2014: An outstanding year for Stereo Investigator” »

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Recent Noteworthy Stereology Publications

Published papers using unbiased stereology; last updated on 2/04/2016.

starindicates that the researchers did a good job reporting stereological parameters

Exercise leads to the re-emergence of the cholinergic/nestin neuronal phenotype within the medial septum/diagonal band and subsequent rescue of both hippocampal ACh efflux and spatial behavior

The Topographic Organization of Retinal Ganglion Cell Density and Spatial Resolving Power in an Unusual Arboreal and Slow-Moving Strepsirhine Primate, the Potto (Perodicticus potto)

starRevisiting adult neurogenesis and the role of erythropoietin for neuronal and oligodendroglial differentiation in the hippocampus

starstarReduction in parvalbumin expression not loss of the parvalbumin-expressing GABA interneuron subpopulation in genetic parvalbumin and shank mouse models of autism

Continuous Collection of AAV from Producer Cell Media Significantly Increases Total Viral Yield

LRRK2 G2019S transgenic mice display increased susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity

Systemic Central Nervous System (CNS)-targeted Delivery of Neuropeptide Y (NPY) Reduces Neurodegeneration and Increases Neural Precursor Cell Proliferation in a Mouse Model of Alzheimer Disease

Active immunization against vasoactive intestinal polypeptide decreases neuronal recruitmetnt and inhibits reproduction in zebra finches

Neuroinflammation in primary blast neurotrauma: Time course and prevention by torso shielding

Characterization of a new low-dose 6-hydroxydopamine model of Parkinson’s disease in rat

starSingle injection of small-molecule amyloid accelerator results in cell death of nigral dopamine neurons in mice

Mitochondria controlled by UCP2 determine hypoxia-induced synaptic remodeling in the cortex and hippocampus

GSK3β isoform-selective regulation of depression, memory and hippocampal cell proliferation

Density of GFAP-immunoreactive astrocytes is decreased in left hippocampi in major depressive disorder

Changes in the disposition of substance P in the rostral ventromedial medulla after inflammatory injury in the rat

Dose-Dependent Neuroprotection and Neurotoxicity of Simvastatin through Reduction of Farnesyl Pyrophosphatein Mice Treated with Intracerebroventricular Injection of Aβ 1 – 42

Efficacy of Combined Use of Different Nickel-Titanium Files on Removing Root Canal Filling Materials

Aquaporin-4 mediates communication between astrocyte and microglia: Implications of neuroinflammation in experimental Parkinson’s disease

The effects of ankaferd blood stopper and microporous polysaccharide hemospheres on epidural fibrosis in rat laminectomy model

Delays in GABAergic Interneuron Development and Behavioral Inhibition after Prenatal Stress

Cocaine self-administration and extinction leads to reduced GFAP expression and morphometric features of astrocytes in the nucleus accumbens core

Aquaporin-4 deficiency diminishes the differential degeneration of midbrain dopaminergic neurons in experimental Parkinson’s disease

Attentional function and basal forebrain cholinergic neuron morphology during aging in the Ts65Dn mouse model of Down syndrome

Different Methods for Evaluating the Effects of Microwave Radiation Exposure on the Nervous System

Dorsal and ventral aspects of the most caudal medullary reticular formation have differential roles in modulation and formation of the respiratory motor pattern in rat

starTaste bud-derived BDNF is required to maintain normal amounts of innervation to adult taste buds

Early mood behavioral changes following exposure to monotonous environment during isolation stress is associated with altered hippocampal synaptic plasticity in male rats

Radiological, stereological, and microscopic evaluation of the quality of canal fillings in oval-shaped root canals prepared with self-adjusting file

Cerebroprotection of Flavanol (-)-Epicatechin after Traumatic Brain Injury via Nrf2-dependent and –independent Pathways

Genetic blockade of the dopamine D3 receptor enhances hippocampal expression of PACAP and receptors and alters their cortical distribution

Combined motor cortex and spinal cord neuromodulation promotes corticospinal system functional and structural plasticity and motor function after injury

Selective VIP Receptor Agonists Facilitate Immune Transformation for Dopaminergic Neuroprotection in MPTP-Intoxicated Mice

Abnormal labyrinthine zone in the Hectd1-null placenta

MDMA Increases Excitability in the Dentate Gyrus: Role of 5HT2A Receptor Induced PGE2 Signaling

 

Continue reading “Recent Noteworthy Stereology publications”

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developers of Stereo Investigator, the world’s most cited stereology system