What is Stereology.info?
Stereology.info, the Stereology Information Center, includes a wide range of knowledge about stereology. This site introduces both basic and advanced concepts in the field. The emphasis is on its use in biological research, though anyone interested in learning concepts of stereology will find something of interest. The application of stereological methods to biological studies permits researchers to effectively and efficiently gather data. This site is dedicated to helping researchers understand the principles of design-based stereology and its advantages over less sophisticated approaches in quantitative histology.
Design-based stereology is a set of methods to ensure rigorous quantitative analysis of the size, shape, and number of objects. When properly used, stereology plays an important role in validating and rejecting experimental hypotheses in biological research. It produces results that are unbiased, efficient, and more reliable than other ad hoc quantitative analyses. Unbiased stereology provides an important contribution to the advancement in biological research by improving the consistency and dependability of quantitative analytical results produced in the laboratory and reported in scientific publications.
Recent Noteworthy Stereology Publications
Published papers using Stereology; last updated on 08/20/2014, * indicates an example where a good job was done reporting stereological parameters
Transplantation of Neural Stem Cells Clonally Derived from Embryonic Stem Cells Promotes Recovery of the Injured Mouse Spinal Cord
Fgfr1 Inactivation in the Mouse Telencephalon Results in Impaired Maturation of Interneurons Expressing Parvalbumin
Spinal Cord Injury Causes Brain Inflammation Associated with Cognitive and Affective Changes: Role of Cell Cycle Pathways
Neuropathology of the Anterior Midcingulate Cortex in Young Children With Autism.
BAG1 is Neuroprotective in In Vivo and In Vitro Models of Parkinson’s Disease
Sociosexual and Communication Deficits after Traumatic Injury to the Developing Murine Brain *
Hepatoprotective Effects of B-1,3-(D)-Glucan on Bortezomib-Induced Liver Damage in Rats
Analysis in conditional cannabinoid 1 receptor-knockout mice reveals neuronal subpopulation-specific effects on epileptogenesis in the kindling paradigm
Novel mGluR5 Positive Allosteric Modulator Improves Functional Recovery, Attenuates Neurodegeneration, and Alters Microglial Polarization after Experimental Traumatic Brain Injury
(G2019S) LRRK2 causes early-phase dysfunction of SNpc dopaminergic neurons and impairment of corticostriatal long-term depression in the PD transgenic mouse
The capsaicin receptor TRPV1 as a novel modulator of neural precursor cell proliferation
Multiple Factors Contribute to the Peripheral Induction of Cerebral β-Amyloidosis
Effects of prenatal 900 MHz electromagnetic field exposures on the histology of rat kidney
Characterization of the role of adult neurogenesis in touch-screen discrimination learning
Investigation of the effect of telmisartan on experimentally induced peripheral nerve injury in rats
RELN-expressing neuron density in layer I of the superior temporal lobe is similar in human brains with autism and in age-matched controls
A cognitive rehabilitation paradigm effective in male rats lacks efficacy in female rats
Downregulation of miR-23a and miR-27a following Experimental Traumatic Brain Injury Induces Neuronal Cell Death through Activation of Proapoptotic Bcl-2 Proteins
Rehabilitative Training Promotes Rapid Motor Recovery but Delayed Motor Map Reorganization in a Rat Cortical Ischemic Infarct Model
Selective increase of in vivo firing frequencies in DA SN neurons after proteasome inhibition in the ventral midbrain
Poly(lactic-co-glycolic) acid microspheres encapsulated in Pluronic F-127 prolong hirudin delivery and improve functional recovery from a demyelination lesion
RECOMBINANT ADENO-ASSOCIATED VIRUS-MEDIATED EXPRESSION OF FRACTALKINE FOR TREATMENT OF NEUROINFLAMMATORY AND NEURODEGENERATIVE DISEASES
Reduced GABAergic Inhibition in the Basolateral Amygdala and the Development of Anxiety-Like Behaviors after Mild Traumatic Brain Injury *
Cerebrolysin™ efficacy in a transgenic model of tauopathy: role in regulation of mitochondrial structure *
Ataxia and Purkinje cell degeneration in mice lacking the CAMTA1 transcription factor
Treatment with α-lipoic acid enhances the bone healing after femoral fracture model of rats
The role of the area postrema in the anorectic effects of amylin and salmon calcitonin: behavioral and neuronal phenotyping
Enhancing Astrocytic Lysosome Biogenesis Facilitates Aβ Clearance and Attenuates Amyloid Plaque Pathogenesis
Heterozygous deletion of the Williams-Beuren syndrome critical interval in mice recapitulates most features of the human disorder
Remodeling of the piriform cortex after lesion in adult rodents.
Different reactions to irradiation in the juvenile and adult hippocampus
Enhancement of Neuroblast Migration into the Injured Cerebral Cortex using Laminin-containing Porous Sponge
Differential distribution of hypoxia-inducible factor 1-beta (ARNT or ARNT2) in mouse substantia nigra and ventral tegmental area
Reducing C-Terminal-Truncated Alpha-Synuclein by Immunotherapy Attenuates Neurodegeneration and Propagation in Parkinson’s Disease-Like Models
The comparison of the viability of crushed, morselized and diced cartilage grafts: a confocal microscopic study
Altered selenium status in Huntington’s disease: Neuroprotection by selenite in the N171-82Q mouse model
Influenza vaccination during early pregnancy contributes to neurogenesis and behavioral function in offspring
Stage-dependent nigral neuronal loss in incidental Lewy body and Parkinson’s disease
Functional correlates of central white matter maturation in perinatal period in rabbits
Maintenance of bladder innervation in diabetes: A stereological study of streptozotocin-treated female rats
FGF/FGFR2 Signaling Regulates the Generation and Correct Positioning of Bergmann Glia Cells in the Developing Mouse Cerebellum
Recommended Stereology Workshops and Courses
Iowa Microscopy Society Meeting
September 26, 2014
University of Iowa
Iowa City, Iowa (USA)
Organizer: Dr. Julie Korich
Dr. Julie Korich, Staff Scientist, will be presenting at the annual Iowa Microscopy Society meeting. Her talk is titled “Using Design Based Stereology in Scientific Studies” The presentation will focus on real world examples of using design-based stereology in research studies.
Organized by Professor Mark West
November 13-14, 2014
The Westin Washington, D.C. City Center
Washington, D.C. (USA)
The goal of the workshop is to teach a small group of research scientists how to design, supervise, and critically evaluate stereological studies of the nervous system. Stereology is a methodology that provides meaningful quantitative descriptions of the geometry of three-dimensional structures from measurements that are made on two-dimensional images sampled from a structure of interest. The workshop will emphasize modern ”design based” stereology, which is characterized by the preparation and probing of tissue in such a manner that no assumptions about the size, shape, and orientation of the structures being quantified are necessary.
The target audience includes neuroscience research scientists working at the graduate student, post-doctoral, and senior scientists who are interested in the practical application of design based stereological methods. The number of participants will be limited to 30, to ensure robust faculty-student interaction.
Note: MBF Bioscience only recommends courses and workshops taught by capable and qualified instructors with no commercial affiliations.
Sponsored by MBF Bioscience
developers of Stereo Investigator, the world’s most cited stereology system