The Most Comprehensive Source of Stereology Information on the Web

What is Stereology.info?

Stereology.info, the Stereology Information Center, includes a wide range of knowledge about stereology. This site introduces both basic and advanced concepts in the field. The emphasis is on its use in biological research, though anyone interested in learning concepts of stereology will find something of interest. The application of stereological methods to biological studies permits researchers to effectively and efficiently gather data. This site is dedicated to helping researchers understand the principles of design-based stereology and its advantages over less sophisticated approaches in quantitative histology.

Design-based stereology is a set of methods to ensure rigorous quantitative analysis of the size, shape, and number of objects. When properly used, stereology plays an important role in validating and rejecting experimental hypotheses in biological research. It produces results that are unbiased, efficient, and more reliable than other ad hoc quantitative analyses. Unbiased stereology provides an important contribution to the advancement in biological research by improving the consistency and dependability of quantitative analytical results produced in the laboratory and reported in scientific publications.

The Counting Frame is a fundamental tool in stereological research.

Stereo Investigator continues to be the leading stereology system

In 2014 researchers used Stereo Investigator in 698 peer-reviewed papers – citing it nearly three times as all other stereology systems combined. These researchers tell us the reasons it continues to be the most widely used system for unbiased stereology are:

  1. it works with many different microscopes and imaging technologies
  2. it provides unbiased data about neuron populations and regions of interest
  3. of the with strong technical and research support provided by MBF Bioscience
2014
source: google scholar

Dr. Mark West, co-developer of the Optical Fractionator stereology probe and Professor of Medical Neurobiology at Aarhus University in Denmark, sums up why Stereo Investigator was cited in so many more publications than all other stereology systems combined: “Stereo Investigator is the most reliable tool for collecting unbiased stereology data. It’s backed by excellent technical and research support teams at MBF – you can call to ask about stereology probes, tissue preparation, microscope hardware, basically anything regarding your stereology study.”

Continue reading “2014: An outstanding year for Stereo Investigator” »

 

Recent Noteworthy Stereology Publications

Published papers using unbiased stereology; last updated on 03/17/2014.

starindicates that the researchers did a good job reporting stereological parameters.

Developmental Trajectories of Auditory Cortex Synaptic Structures and Gap-Prepulse Inhibition of Acoustic Startle Between Early Adolescence and Young Adulthood in Mice

Maternal vitamin D deficiency alters fetal brain development in the BALB/c mouse

A stereological analysis of NPY, POMC, orexin, GFAP astrocyte and Iba1 microglia cell number and volume in diet-induced obese male mice

Impaired Leptomeningeal Collateral Flow Contributes to the Poor Outcome following Experimental Stroke in the Type 2 Diabetic Mice

The Loss of Glucose Regulated Protein 78 (GRP78) during Normal Aging or from siRNA Knockdown Augments Human Alpha-Synuclein (α-syn) Toxicity to Rat Nigral Neurons

C–C chemokine receptor type 2 (CCR2) signaling protects neonatal male mice with hypoxic–ischemic hippocampal damage from developing spatial learning deficits

Amitriptyline Improves Motor Function via Enhanced Neurotrophin Signaling and Mitochondrial Functions in the Murine N171-82Q Huntington’s Disease Model

Maternal Inflammation Contributes to Brain Overgrowth and Autism-Associated Behaviors through Altered Redox Signaling in Stem and Progenitor Cells

Specific Amyloid β Clearance by a Catalytic Antibody Construct

starDonepezil Rescues Spatial Learning and Memory Deficits following Traumatic Brain Injury Independent of Its Effects on Neurogenesis

Chondroitin Sulfate Proteoglycans Negatively Modulate Spinal Cord Neural Precursor Cells by Signaling through LAR and RPTPσ and modulation of the Rho/ROCK Pathway

Inhibition of 14-3-3 Proteins Leads to Schizophrenia-Related Behavioral Phenotypes and Synaptic Defects in Mice

Gene Dosage Dependent Aggravation of the Neurological Phenotype in the 5XFAD Mouse Model of Alzheimer’s Disease

Automated High Performance Analysis of Lung Morphometry

Near infrared light mitigates cerebellar pathology in transgenic mouse models of dementia

Masculinization of the Zebra Finch Song System: Roles of Oestradiol and the Z-chromosome Gene Tubulin Specific Chaperone Protein A

Protection from cyanide-induced brain injury by the Nrf2 transcriptional activator carnosic acid

αCaMKII autophosphorylation mediates neuronal activation in the hippocampal dentate gyrus after alcohol and cocaine in mice

A rat model of nerve agent exposure applicable to the pediatric population: The anticonvulsant efficacies of atropine and GluK1 antagonists

starA partial lesion model of Parkinson’s disease in mice – Characterization of a 6-OHDA-induced medial forebrain bundle lesion

Administration of Umbilical Cord Blood Cells Transiently Decreased Hypoxic-Ischemic Brain Injury in Neonatal Rats

Imipramine protects against the deleterious effects of chronic corticosterone on depression-like behavior, hippocampal reelin expression, and neuronal maturation

Mitotic events in cerebellar granule progenitor cells that expand cerebellar surface area are critical for normal cerebellar cortical lamination in mice.

Chronic P7C3 treatment restores hippocampal neurogenesis

Neonatal iron supplementation potentiates oxidative stress, energetic dysfunction and neurodegeneration in the R6/2 mouse model of Huntington’s disease

starGlucose and oxygen metabolism after penetrating ballistic-like brain injury

Continue reading “Recent Noteworthy Stereology publications”

 

 

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developers of Stereo Investigator, the world’s most cited stereology system