The Most Comprehensive Source of Stereology Information on the Web


What is, the Stereology Information Center, includes a wide range of knowledge about stereology. This site introduces both basic and advanced concepts in the field. The emphasis is on its use in biological research, though anyone interested in learning concepts of stereology will find something of interest. The application of stereological methods to biological studies permits researchers to effectively and efficiently gather data. This site is dedicated to helping researchers understand the principles of design-based stereology and its advantages over less sophisticated approaches in quantitative histology.

Design-based stereology is a set of methods to ensure rigorous quantitative analysis of the size, shape, and number of objects. When properly used, stereology plays an important role in validating and rejecting experimental hypotheses in biological research. It produces results that are unbiased, efficient, and more reliable than other ad hoc quantitative analyses. Unbiased stereology provides an important contribution to the advancement in biological research by improving the consistency and dependability of quantitative analytical results produced in the laboratory and reported in scientific publications.

The Counting Frame is a fundamental tool in stereological research.

Recent Noteworthy Stereology Publications

Published papers using stereology; last updated on 09/11/2014, star indicates that the researchers did an exemplary job reporting stereological parameters

Intravenous immunoglobulin G improves neurobehavioral and histological outcomes after traumatic brain injury in mice

Conditional Deletion of α-CaMKII Impairs Integration of Adult-Generated Granule Cells into Dentate Gyrus Circuits and Hippocampus-Dependent Learning

Early Expression of Hypocretin/Orexin in the Chick Embryo Brain

star Cannabinoid CB2 receptor (CB2R) stimulation delays rubrospinal mitochondrial-dependent degeneration and improves functional recovery after spinal cord hemisection by ERK1/2 inactivation

Regulation of fibroblast lipid-storage and myofibroblast phenotypes during alveolar septation in mice

Hippocampal Y2 receptor-mediated mossy fiber plasticity is implicated in nicotine abstinence-related social anxiety-like behavior in an outbred rat model of the novelty-seeking phenotype

Limbic but not non-limbic kindling impairs conditioned fear and promotes plasticity of NPY and its Y2 receptor

Intravenous Immunoglobulin Reduces Tau Pathology and Preserves Neuroplastic Gene Expression in the 3xTg Mouse Model of Alzheimer’s Disease

Transplantation of Neural Stem Cells Clonally Derived from Embryonic Stem Cells Promotes Recovery of the Injured Mouse Spinal Cord

Fgfr1 Inactivation in the Mouse Telencephalon Results in Impaired Maturation of Interneurons Expressing Parvalbumin

Spinal Cord Injury Causes Brain Inflammation Associated with Cognitive and Affective Changes: Role of Cell Cycle Pathways

Neuropathology of the Anterior Midcingulate Cortex in Young Children With Autism.

BAG1 is Neuroprotective in In Vivo and In Vitro Models of Parkinson’s Disease

star Sociosexual and Communication Deficits after Traumatic Injury to the Developing Murine Brain

Hepatoprotective Effects of B-1,3-(D)-Glucan on Bortezomib-Induced Liver Damage in Rats

Analysis in conditional cannabinoid 1 receptor-knockout mice reveals neuronal subpopulation-specific effects on epileptogenesis in the kindling paradigm

Novel mGluR5 Positive Allosteric Modulator Improves Functional Recovery, Attenuates Neurodegeneration, and Alters Microglial Polarization after Experimental Traumatic Brain Injury


Recommended Stereology Workshops and Courses

NeuroStereology Workshop

Organized by Professor Mark West
November 13-14, 2014
The Westin Washington, D.C. City Center
Washington, D.C. (USA)

Short Description
The goal of the workshop is to teach a small group of research scientists how to design, supervise, and critically evaluate stereological studies of the nervous system. Stereology is a methodology that provides meaningful quantitative descriptions of the geometry of three-dimensional structures from measurements that are made on two-dimensional images sampled from a structure of interest. The workshop will emphasize modern ”design based” stereology, which is characterized by the preparation and probing of tissue in such a manner that no assumptions about the size, shape, and orientation of the structures being quantified are necessary.

The target audience includes neuroscience research scientists working at the graduate student, post-doctoral, and senior scientists who are interested in the practical application of design based stereological methods. The number of participants will be limited to 30, to ensure robust faculty-student interaction.


Note: MBF Bioscience only recommends courses and workshops taught by capable and qualified instructors with no commercial affiliations.



Sponsored by MBF Bioscience
developers of Stereo Investigator, the world’s most cited stereology system